PDBsum entry 4zru

Acetylcholine binding protein

PDB id: 4zru

Contents

Protein chains

(+ 4 more) 211 a.a.

Ligands

PO4 ×10

TI9 ×10

Waters ×1550

PDB id:

4zru

Name:

Acetylcholine binding protein

Title:

X-ray crystal structure of lymnaea stagnalis acetylcholine binding protein (ls-achbp) in complex with 3-[2-[(2s)-pyrrolidin-2- yl]ethynyl]pyridine (ti-5180)

Structure:

Acetylcholine-binding protein. Chain: a, b, c, d, e, f, g, h, i, j. Fragment: unp residues 20-229. Synonym: achbp. Engineered: yes

Source:

Lymnaea stagnalis. Great pond snail. Organism_taxid: 6523. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s gnti-

Resolution:

1.90Å R-factor: 0.173 R-free: 0.205

Authors:

J.Bobango,B.Sankaran,J.F.Park,J.Wu,T.T.Talley

Key ref:

T.T.Talley Comparisons of binding affinities for neuronal nicoti receptors (nnrs) and achbps, And structural features high-Affinity, Non-Selective nnr ligand-Achbp co-Crys structure. To be published, .

Date:

12-May-15 Release date: 27-May-15

Protein chains

P58154  (ACHP_LYMST) -  Acetylcholine-binding protein from Lymnaea stagnalis

Seq: 229 a.a.

Struc: 211 a.a.*

* PDB and UniProt seqs differ at 8 residue positions (black crosses)