PDBsum entry 4xrd

Oxidoreductase

PDB id: 4xrd

Contents

Protein chains

164 a.a.

Ligands

SO4

Metals

__K ×3

_CL ×5

Waters ×390

PDB id:

4xrd

Name:

Oxidoreductase

Title:

Salmonella typhimurium ahpc w169f mutant

Structure:

Alkyl hydroperoxide reductase subunit c. Chain: a, b, c, d, e. Synonym: alkyl hydroperoxide reductase protein c22,peroxiredoxin, thioredoxin peroxidase. Engineered: yes. Mutation: yes

Source:

Salmonella enterica subsp. Enterica serovar typhimurium. Organism_taxid: 90371. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.30Å R-factor: 0.194 R-free: 0.239

Authors:

A.Perkins,K.Nelson,D.Parsonage,L.Poole,P.A.Karplus

Key ref:

K.J.Nelson et al. (2018). Experimentally Dissecting the Origins of Peroxiredoxin Catalysis. Antioxid Redox Signal, 28, 521-536. PubMed id: 28375740 DOI: 10.1089/ars.2016.6922

Date:

21-Jan-15 Release date: 27-Jan-16

Protein chains

P0A251  (AHPC_SALTY) -  Alkyl hydroperoxide reductase C from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

Seq: 187 a.a.

Struc: 164 a.a.

Enzyme reactions

• Enzyme class: E.C.1.11.1.26 - NADH-dependent peroxiredoxin.
• Reaction: a hydroperoxide + NADH + H⁺ = an alcohol + NAD⁺ + H2O

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

DOI no: 10.1089/ars.2016.6922

Antioxid Redox Signal 28:521-536 (2018)

PubMed id: 28375740

Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.

K.J.Nelson, A.Perkins, A.E.D.Van Swearingen, S.Hartman, A.E.Brereton, D.Parsonage, F.R.Salsbury, P.A.Karplus, L.B.Poole.

ABSTRACT

No abstract given.