PDBsum entry 4x3c

Hydrolase

PDB id: 4x3c

Contents

Protein chain

534 a.a.

Ligands

NAG-NAG

NAG

TNH

Waters ×184

PDB id:

4x3c

Name:

Hydrolase

Title:

Torpedo californica acetylcholinesterase in complex with a tacrine- nicotinamide hybrid inhibitor

Structure:

Acetylcholinesterase. Chain: a. Fragment: unp residues 23-556. Synonym: ache. Ec: 3.1.1.7

Source:

Torpedo californica. Pacific electric ray. Organism_taxid: 7787

Resolution:

2.60Å R-factor: 0.222 R-free: 0.280

Authors:

A.Pesaresi,D.Lamba

Key ref:

A.Pesaresi and d.lamba Torpedo californica acetylcholinesterase in complex w tacrine-Nicotinamide hybrid inhibitor. To be published, .

Date:

28-Nov-14 Release date: 23-Dec-15

Protein chain

P04058  (ACES_TETCF) -  Acetylcholinesterase from Tetronarce californica

Seq: 586 a.a.

Struc: 534 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.1.7 - acetylcholinesterase.
• Reaction: acetylcholine + H2O = choline + acetate + H⁺

acetylcholine (Bound ligand (Het Group name = NAG) matches with 41.18% similarity) + H2O = choline + acetate + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site