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PDBsum entry 4tyh
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Transferase/transferase inhibitor
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PDB id
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4tyh
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PDB id:
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| Name: |
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Transferase/transferase inhibitor
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Title:
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Ternary complex of p38 and mk2 with a p38 inhibitor
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Structure:
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Map kinase-activated protein kinase 2. Chain: a. Fragment: unp residues 51-400. Synonym: mk2. Engineered: yes. Mitogen-activated protein kinase 14. Chain: b. Fragment: unp residues 6-353. Synonym: mapk 14,crk1,mitogen-activated protein kinase p38 alpha,map
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: mapkapk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. Mouse. Organism_taxid: 10090.
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Resolution:
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3.00Å
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R-factor:
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0.232
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R-free:
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0.313
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Authors:
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J.G.Cumming,J.E.Debreczeni,F.Edfeldt,F.Evertsson,M.Harrison, G.Holdgate,M.James,S.Lamont,K.Oldham,J.E.Sullivan,S.Wells
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Key ref:
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J.G.Cumming
Discovery of substrate selective, Atp-Competitive p38 map kinase inhibitors.
To be published,
.
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Date:
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08-Jul-14
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Release date:
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22-Jul-15
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PROCHECK
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Headers
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References
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Enzyme class 1:
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Chain A:
E.C.2.7.11.1
- non-specific serine/threonine protein kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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Enzyme class 2:
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Chain B:
E.C.2.7.11.24
- mitogen-activated protein kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
