PDBsum entry 4rvb

Hydrolase

PDB id: 4rvb

Contents

Protein chain

607 a.a.

Ligands

ACT ×2

IMD ×3

GOL ×2

ACY ×2

Metals

_YB

_ZN

Waters ×564

PDB id:

4rvb

Name:

Hydrolase

Title:

Crystal structure analysis of the human leukotriene a4 hydrolase

Structure:

Leukotriene a-4 hydrolase. Chain: a. Synonym: lta-4 hydrolase, leukotriene a(4) hydrolase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: lta4h, lta4. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.93Å R-factor: 0.146 R-free: 0.178

Authors:

P.Ouyang,W.Lu,K.Cui,J.Huang

Key ref:

P.Ouyang et al. Crystal structure analysis of the human leukotriene a hydrolase. To be published, .

Date:

25-Nov-14 Release date: 02-Dec-15

Protein chain

P09960  (LKHA4_HUMAN) -  Leukotriene A-4 hydrolase from Homo sapiens

Seq: 611 a.a.

Struc: 607 a.a.

Enzyme reactions

• Enzyme class 2: E.C.3.3.2.6 - leukotriene-A4 hydrolase.
• Reaction: leukotriene A4 + H2O = leukotriene B4
• Cofactor: Zn(2+)
• Enzyme class 3: E.C.3.4.11.4 - tripeptide aminopeptidase.
• Reaction: Release of a N-terminal residue from a tripeptide.
• Cofactor: Zn(2+)

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site