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PDBsum entry 4p01

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protein ligands metals Protein-protein interface(s) links
Isomerase/isomerase inhibitor PDB id
4p01
Jmol
Contents
Protein chains
114 a.a.
Ligands
1ZW ×2
IPA ×2
GOL
Metals
_CL ×3
Waters ×182
PDB id:
4p01
Name: Isomerase/isomerase inhibitor
Title: Crystal structure analysis of macrophage migration inhibitor in complex with n-[(4-cyanophenyl)methyl]methanethioamide
Structure: Macrophage migration inhibitory factor. Chain: a, b, c. Synonym: mif, glycosylation-inhibiting factor, gif, l-dopac isomerase, l-dopachrome tautomerase, phenylpyruvate tautome engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mif, glif, mmif. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_cell_line: bl21(de3)
Resolution:
2.07Å     R-factor:   0.188     R-free:   0.228
Authors: G.Pantouris,E.Lolis
Key ref: G.Pantouris and e.lolis To be published. To be published, .
Date:
19-Feb-14     Release date:   19-Mar-14    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P14174  (MIF_HUMAN) -  Macrophage migration inhibitory factor
Seq:
Struc:
115 a.a.
114 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class 2: E.C.5.3.2.1  - Phenylpyruvate tautomerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Keto-phenylpyruvate = enol-phenylpyruvate
Keto-phenylpyruvate
= enol-phenylpyruvate
   Enzyme class 3: E.C.5.3.3.12  - L-dopachrome isomerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
      Reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate
L-dopachrome
= 5,6-dihydroxyindole-2-carboxylate
      Cofactor: Zn(2+)
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   5 terms 
  Biological process     immune system process   37 terms 
  Biochemical function     chemoattractant activity     8 terms