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PDBsum entry 4mza

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protein ligands metals Protein-protein interface(s) links
Hydrolase PDB id
4mza
Jmol
Contents
Protein chains
432 a.a.
Ligands
NAG ×2
NAG-NAG-BMA-MAN-
MAN-MAN-MAN-MAN-
MAN
EDO ×5
SO4 ×2
NAG-NAG-BMA-MAN
NAG-NAG-BMA
NAG-FUL
PO4 ×2
Metals
_CA ×2
Waters ×550
PDB id:
4mza
Name: Hydrolase
Title: Crystal structure of hpiv3 hemagglutinin-neuraminidase
Structure: Hemagglutinin-neuraminidase. Chain: a, b. Fragment: catalytic domain (unp residues 136-572). Engineered: yes
Source: Human parainfluenza 3 virus. Hpiv-3. Organism_taxid: 11217. Strain: wash/47885/57. Gene: hn. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: hi5.
Resolution:
1.65Å     R-factor:   0.168     R-free:   0.198
Authors: R.Xu,I.A.Wilson
Key ref: R.Xu et al. (2013). Interaction between the hemagglutinin-neuraminidase and fusion glycoproteins of human parainfluenza virus type III regulates viral growth in vivo. MBio, 4, e00803. PubMed id: 24149514 DOI: 10.1128/mBio.00803-13
Date:
29-Sep-13     Release date:   06-Nov-13    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P08492  (HN_PI3H4) -  Hemagglutinin-neuraminidase
Seq:
Struc:
 
Seq:
Struc:
572 a.a.
432 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.2.1.18  - Exo-alpha-sialidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     viral envelope   1 term 
  Biological process     viral infectious cycle   1 term 
  Biochemical function     host cell surface receptor binding     2 terms  

 

 
DOI no: 10.1128/mBio.00803-13 MBio 4:e00803 (2013)
PubMed id: 24149514  
 
 
Interaction between the hemagglutinin-neuraminidase and fusion glycoproteins of human parainfluenza virus type III regulates viral growth in vivo.
R.Xu, S.G.Palmer, M.Porotto, L.M.Palermo, S.Niewiesk, I.A.Wilson, A.Moscona.
 
  ABSTRACT  
 
No abstract given.