CA inhibitors: Human carbonic anhydrases (CAs) are diagnostic and therapeutic
targets. Various carborane cages are shown to act as active-site-directed
inhibitors, and substitution with a sulfamide group and other substituents leads
to compounds with high selectivity towards the cancer-specific isozyme IX.
Crystal structures of the carboranes in the active site provide information that
can be applied to the structure-based design of specific inhibitors.