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PDBsum entry 4m1c
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Contents |
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957 a.a.
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205 a.a.
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175 a.a.
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206 a.a.
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184 a.a.
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PDB id:
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Hydrolase
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Title:
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Crystal structure analysis of fab-bound human insulin degrading enzyme (ide) in complex with amyloid-beta (1-40)
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Structure:
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Insulin-degrading enzyme. Chain: a, b. Synonym: abeta-degrading protease, insulin protease, insulinase, insulysin. Engineered: yes. Mutation: yes. Fab-bound ide, heavy chain. Chain: c, e. Engineered: yes.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ide, insulin degrading enzyme. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: specific antigen-binding fragment (fab, light chain) synthetically engineered to target human insulin degrading enzyme.
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Resolution:
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3.50Å
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R-factor:
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0.230
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R-free:
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0.270
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Authors:
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L.M.Mccord,W.Liang,M.Farcasanu,K.Scherpelz,S.C.Meredith,S.Koide, W.J.Tang
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Key ref:
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L.A.Mccord
et al.
Crystal structure analysis of FAB-Bound human insulin degrading enzyme (ide) in complex with amyloid-Beta (.
To be published,
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Date:
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02-Aug-13
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Release date:
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06-Aug-14
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PROCHECK
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Headers
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References
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P14735
(IDE_HUMAN) -
Insulin-degrading enzyme from Homo sapiens
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Seq:
Struc:
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1019 a.a.
957 a.a.*
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Links
