PDBsum entry 4lg0

Transcription/DNA

PDB id: 4lg0

Contents

Protein chains

89 a.a.

106 a.a.

DNA/RNA

Ligands

PG4

Metals

_CA

Waters ×70

PDB id:

4lg0

Name:

Transcription/DNA

Title:

Structure of a ternary foxo1-ets1 DNA complex

Structure:

Forkhead box protein o1. Chain: a. Fragment: DNA binding domain, unp residues 143-270. Synonym: forkhead box protein o1a, forkhead in rhabdomyosarcoma. Engineered: yes. Protein c-ets-1. Chain: b. Fragment: DNA binding domain, unp residues 331-440. Synonym: p54.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: fkhr, foxo1, foxo1a. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: c-ets-1, ets1, ewsr2. Synthetic: yes. Other_details: this sequence occurs naturally in humans..

Resolution:

2.19Å R-factor: 0.197 R-free: 0.243

Authors:

G.Birrane,W.C.Choy,D.Datta,C.A.Geiger,M.A.Grant

Key ref:

G.Birrane et al. Structure of a ternary foxo1-Ets1 DNA complex. To be published, .

Date:

27-Jun-13 Release date: 02-Jul-14

Protein chain

Q12778  (FOXO1_HUMAN) -  Forkhead box protein O1 from Homo sapiens

Seq: 655 a.a.

Struc: 89 a.a.

Protein chain

P14921  (ETS1_HUMAN) -  Protein C-ets-1 from Homo sapiens

Seq: 441 a.a.

Struc: 106 a.a.

DNA/RNA chains

T-T-C-A-C-G-G-T-T-T-C-C-T-G-T-T-A-T-T-G-T 21 bases

A-A-A-C-A-A-T-A-A-C-A-G-G-A-A-A-C-C-G-T-G 21 bases