PDBsum entry 4l6b

Hydrolase/hydrolase inhibitor

PDB id: 4l6b

Contents

Protein chain

330 a.a.

Ligands

DMS ×2

1VS

GOL

Waters ×324

PDB id:

4l6b

Name:

Hydrolase/hydrolase inhibitor

Title:

Endothiapepsin in complex with thiophen-based inhibitor sap128

Structure:

Endothiapepsin. Chain: a. Fragment: unp residues 90-419. Synonym: aspartate protease. Ec: 3.4.23.22

Source:

Cryphonectria parasitica. Chesnut blight fungus. Organism_taxid: 5116

Resolution:

1.37Å R-factor: 0.167 R-free: 0.197

Authors:

A.Park,A.Heine,G.Klebe

Key ref:

M.Kuhnert et al. Endothiapepsin in complex with thiophen based inhibit. To be published, .

Date:

12-Jun-13 Release date: 18-Jun-14

Protein chain

P11838  (CARP_CRYPA) -  Endothiapepsin from Cryphonectria parasitica

Seq: 419 a.a.

Struc: 330 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.23.22 - endothiapepsin.
• Reaction: Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but does not cleave 14-Ala-|-Leu-15 in the B chain of insulin or Z-Glu-Tyr. Clots milk.