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PDBsum entry 4jnl

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protein ligands links
Hydrolase/hydrolase inhibitor PDB id
4jnl
Jmol
Contents
Protein chain
246 a.a.
Ligands
PZH
SO4
Waters ×39
PDB id:
4jnl
Name: Hydrolase/hydrolase inhibitor
Title: Crystal structure of upa in complex with its inhibitor 4- bromobenzylamine at ph 7.4
Structure: Urokinase-type plasminogen activator. Chain: u. Fragment: catalytic domain. Synonym: u-plasminogen activator, upa. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
Resolution:
2.00Å     R-factor:   0.201     R-free:   0.252
Authors: X.Zhang,L.Jiang,B.Zhao,C.Yuan,M.Huang
Key ref: X.Zhang et al. Halogen bonds in the design of serine protease inhibi. To be published, .
Date:
15-Mar-13     Release date:   19-Mar-14    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00749  (UROK_HUMAN) -  Urokinase-type plasminogen activator
Seq:
Struc:
431 a.a.
246 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.3.4.21.73  - U-plasminogen activator.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     proteolysis   1 term 
  Biochemical function     catalytic activity     2 terms