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PDBsum entry 4jnc

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protein ligands links
Hydrolase/hydrolase inhibitor PDB id
4jnc
Jmol
Contents
Protein chain
312 a.a.
Ligands
1LF
Waters ×238
PDB id:
4jnc
Name: Hydrolase/hydrolase inhibitor
Title: Soluble epoxide hydrolase complexed with a carboxamide inhib
Structure: Bifunctional epoxide hydrolase 2. Chain: a. Fragment: catalytic domain. Synonym: cytosolic epoxide hydrolase 2, ceh, epoxide hydrat soluble epoxide hydrolase, seh, lipid-phosphate phosphatase engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephx2. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Resolution:
1.96Å     R-factor:   0.188     R-free:   0.219
Authors: L.M.Shewchuk
Date:
15-Mar-13     Release date:   05-Jun-13    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P34913  (HYES_HUMAN) -  Bifunctional epoxide hydrolase 2
Seq:
Struc:
 
Seq:
Struc:
555 a.a.
312 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class 2: E.C.3.1.3.76  - Lipid-phosphate phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O = (9S,10S)- 9,10-dihydroxyoctadecanoate + phosphate
(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate
+ H(2)O
= (9S,10S)- 9,10-dihydroxyoctadecanoate
+ phosphate
      Cofactor: Mg(2+)
   Enzyme class 3: E.C.3.3.2.10  - Soluble epoxide hydrolase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: An epoxide + H2O = a glycol
epoxide
+ H(2)O
= glycol
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biochemical function     catalytic activity     1 term