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PDBsum entry 4jby

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protein ligands Protein-protein interface(s) links
Transferase PDB id
4jby
Jmol
Contents
Protein chains
310 a.a.
Ligands
FSK ×2
SO4 ×5
EDO
Waters ×323
PDB id:
4jby
Name: Transferase
Title: Crystal structure of thymidine kinase from herpes simplex vi in complex with f-sk78
Structure: Thymidine kinase. Chain: a, b. Fragment: unp residues 45-376. Synonym: hsv1-tk. Engineered: yes
Source: Human herpesvirus 1. Hhv-1. Organism_taxid: 10299. Strain: 17. Gene: tk, tk (ul23), ul23. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Resolution:
2.00Å     R-factor:   0.177     R-free:   0.218
Authors: L.Pernot,I.Novakovic,Y.Westermaier,R.Perozzo,S.Raic-Malic,L.
Key ref: L.Pernot et al. New thymine derivatives as hsv1-Tk ligand for the development of pet imaging tracer. To be published, .
Date:
20-Feb-13     Release date:   06-Mar-13    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P03176  (KITH_HHV11) -  Thymidine kinase
Seq:
Struc:
376 a.a.
310 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.1.21  - Thymidine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + thymidine = ADP + thymidine 5'-phosphate
ATP
+
thymidine
Bound ligand (Het Group name = FSK)
matches with 73.68% similarity
= ADP
+ thymidine 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     TMP biosynthetic process   1 term 
  Biochemical function     ATP binding     2 terms