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PDBsum entry 4iwv

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protein ligands metals links
Transferase/transferase inhibitor PDB id
4iwv
Jmol
Contents
Protein chain
443 a.a.
Ligands
GLC
1J9
Metals
_NA
Waters ×151
PDB id:
4iwv
Name: Transferase/transferase inhibitor
Title: Crystals structure of human glucokinase in complex with smal activator
Structure: Glucokinase isoform 3. Chain: a. Fragment: glucokinase. Synonym: hexokinase type iv, hk iv, hexokinase-4, hk4, hexo engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gck. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.10Å     R-factor:   0.202     R-free:   0.250
Authors: D.J.Ogg,D.Hargreaves,S.Gerhardt,L.Flavell,M.Mcalister
Key ref: M.J.Waring et al. Optimising pharmacokinetics of glucokinase activators matched triplicate design sets the discovery of azd36 azd9485. To be published, .
Date:
24-Jan-13     Release date:   24-Apr-13    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P35557  (HXK4_HUMAN) -  Glucokinase
Seq:
Struc:
465 a.a.
443 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 9 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.2.7.1.2  - Glucokinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + D-glucose = ADP + D-glucose 6-phosphate
ATP
+
D-glucose
Bound ligand (Het Group name = GLC)
corresponds exactly
= ADP
+ D-glucose 6-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   7 terms 
  Biological process     metabolic process   35 terms 
  Biochemical function     catalytic activity     15 terms