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PDBsum entry 4hma

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protein ligands metals Protein-protein interface(s) links
Hydrolase/hydrolase inhibitor PDB id
4hma
Jmol
Contents
Protein chain
160 a.a.
Ligands
0ZD
GOL ×5
PGO ×6
PEG ×7
MLT
Metals
_ZN ×4
_CA ×6
Waters ×345
PDB id:
4hma
Name: Hydrolase/hydrolase inhibitor
Title: Crystal structure of an mmp twin carboxylate based inhibitor complex with the mmp-9 catalytic domain
Structure: Matrix metalloproteinase-9. Chain: a, b. Fragment: mmp-9 catalytic domain 107-215,391-443. Synonym: mmp-9, 92 kda gelatinase, 92 kda type iv collagena gelatinase b, gelb, 67 kda matrix metalloproteinase-9, 82 k metalloproteinase-9. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: clg4b, mmp9. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.94Å     R-factor:   0.214     R-free:   0.283
Authors: E.A.Stura,C.Antoni,L.Vera,E.Nuti,L.Carafa,E.Cassar-Lajeuness A.Rossello
Key ref: E.Nuti et al. Powerful twin carboxylic inhibitors for mmp homodimerisation.. To be published, .
Date:
18-Oct-12     Release date:   24-Apr-13    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P14780  (MMP9_HUMAN) -  Matrix metalloproteinase-9
Seq:
Struc:
 
Seq:
Struc:
707 a.a.
160 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.3.4.24.35  - Gelatinase B.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Cleavage of gelatin types I and V and collagen types IV and V.
      Cofactor: Calcium; Zinc
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular matrix   1 term 
  Biological process     leukocyte migration   4 terms 
  Biochemical function     metallopeptidase activity     3 terms