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PDBsum entry 4hgv

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protein ligands Protein-protein interface(s) links
Lyase PDB id
4hgv
Jmol
Contents
Protein chains
456 a.a.
411 a.a.
Ligands
SO4 ×3
Waters ×316
PDB id:
4hgv
Name: Lyase
Title: Crystal structure of a fumarate hydratase
Structure: Fumarate hydratase class ii. Chain: a, b, c, d. Synonym: fumarasE C. Engineered: yes
Source: Sinorhizobium meliloti. Organism_taxid: 266834. Strain: 1021. Gene: fumc, r01859, smc00149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
2.09Å     R-factor:   0.199     R-free:   0.234
Authors: S.Eswaramoorthy,B.Evans,R.Foti,A.Gizzi,B.Hillerich,A.Kar,J.L R.Seidel,G.Villigas,W.Zencheck,S.C.Almo,S.Swaminathan,New Y Structural Genomics Research Consortium (Nysgrc)
Key ref: S.Eswaramoorthy et al. Crystal structure of a fumarate hydratase. To be published, .
Date:
08-Oct-12     Release date:   31-Oct-12    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q92PB6  (FUMC_RHIME) -  Fumarate hydratase class II
Seq:
Struc:
463 a.a.
456 a.a.
Protein chain
Pfam   ArchSchema ?
Q92PB6  (FUMC_RHIME) -  Fumarate hydratase class II
Seq:
Struc:
463 a.a.
411 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 5 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chains A, B, C, D: E.C.4.2.1.2  - Fumarate hydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Citric acid cycle
      Reaction: (S)-malate = fumarate + H2O
(S)-malate
= fumarate
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   2 terms 
  Biological process     fumarate metabolic process   2 terms 
  Biochemical function     catalytic activity     3 terms