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PDBsum entry 4hea

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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
4hea
Jmol
Contents
Protein chains
437 a.a.
178 a.a.
756 a.a.
384 a.a.
196 a.a.
161 a.a.
180 a.a.
127 a.a.
127 a.a.
117 a.a.
160 a.a.
95 a.a.
605 a.a.
467 a.a.
427 a.a.
353 a.a.
Ligands
SF4 ×14
FMN ×2
FES ×4
PDB id:
4hea
Name: Oxidoreductase
Title: Crystal structure of the entire respiratory complex i from t thermophilus
Structure: Nadh-quinone oxidoreductase subunit 1. Chain: 1, b. Synonym: nadh dehydrogenase i chain 1, ndh-1 subunit 1. Nadh-quinone oxidoreductase subunit 2. Chain: 2, c. Synonym: nadh dehydrogenase i chain 2, ndh-1 subunit 2. Nadh-quinone oxidoreductase subunit 3. Chain: 3, d. Synonym: nadh dehydrogenase i chain 3, ndh-1 subunit 3.
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Other_details: cytoplasmic membrane. Other_details: cytoplasmic membrane
Resolution:
3.30Å     R-factor:   0.203     R-free:   0.239
Authors: R.Baradaran,J.M.Berrisford,G.S.Minhas,L.A.Sazanov
Key ref: R.Baradaran et al. (2013). Crystal structure of the entire respiratory complex I. Nature, 494, 443-448. PubMed id: 23417064 DOI: 10.1038/nature11871
Date:
03-Oct-12     Release date:   13-Feb-13    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q56222  (NQO1_THET8) -  NADH-quinone oxidoreductase subunit 1
Seq:
Struc:
438 a.a.
437 a.a.
Protein chains
Pfam   ArchSchema ?
Q56221  (NQO2_THET8) -  NADH-quinone oxidoreductase subunit 2
Seq:
Struc:
181 a.a.
178 a.a.
Protein chains
Pfam   ArchSchema ?
Q56223  (NQO3_THET8) -  NADH-quinone oxidoreductase subunit 3
Seq:
Struc:
 
Seq:
Struc:
783 a.a.
756 a.a.
Protein chains
Pfam   ArchSchema ?
Q56220  (NQO4_THET8) -  NADH-quinone oxidoreductase subunit 4
Seq:
Struc:
409 a.a.
384 a.a.
Protein chains
Pfam   ArchSchema ?
Q56219  (NQO5_THET8) -  NADH-quinone oxidoreductase subunit 5
Seq:
Struc:
207 a.a.
196 a.a.
Protein chains
Pfam   ArchSchema ?
Q56218  (NQO6_THET8) -  NADH-quinone oxidoreductase subunit 6
Seq:
Struc:
181 a.a.
161 a.a.
Protein chains
Pfam   ArchSchema ?
Q56224  (NQO9_THET8) -  NADH-quinone oxidoreductase subunit 9
Seq:
Struc:
182 a.a.
180 a.a.
Protein chains
Pfam   ArchSchema ?
Q5SKZ7  (NQO15_THET8) -  NADH-quinone oxidoreductase subunit 15
Seq:
Struc:
129 a.a.
127 a.a.
Protein chains
Pfam   ArchSchema ?
Q5SI52  (Q5SI52_THET8) -  Uncharacterized protein
Seq:
Struc:
131 a.a.
127 a.a.
Protein chains
Pfam   ArchSchema ?
Q56217  (NQO7_THET8) -  NADH-quinone oxidoreductase subunit 7
Seq:
Struc:
119 a.a.
117 a.a.
Protein chains
Pfam   ArchSchema ?
Q56225  (NQO10_THET8) -  NADH-quinone oxidoreductase subunit 10
Seq:
Struc:
176 a.a.
160 a.a.
Protein chains
Pfam   ArchSchema ?
Q56226  (NQO11_THET8) -  NADH-quinone oxidoreductase subunit 11
Seq:
Struc:
95 a.a.
95 a.a.
Protein chains
Pfam   ArchSchema ?
Q56227  (NQO12_THET8) -  NADH-quinone oxidoreductase subunit 12
Seq:
Struc:
 
Seq:
Struc:
606 a.a.
605 a.a.
Protein chains
Pfam   ArchSchema ?
Q56228  (NQO13_THET8) -  NADH-quinone oxidoreductase subunit 13
Seq:
Struc:
469 a.a.
467 a.a.
Protein chains
Pfam   ArchSchema ?
Q56229  (NQO14_THET8) -  NADH-quinone oxidoreductase subunit 14
Seq:
Struc:
427 a.a.
427 a.a.
Protein chains
Pfam   ArchSchema ?
Q60019  (NQO8_THET8) -  NADH-quinone oxidoreductase subunit 8
Seq:
Struc:
365 a.a.
353 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains 1, 2, 3, 4, 5, 6, 9, 7, A, J, K, L, M, N, H, B, C, D, E, F, G, O, I, P, R, S, T, U, V, Q: E.C.1.6.99.5  - Nadh dehydrogenase (quinone).
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: NADH + acceptor = NAD+ + reduced acceptor
NADH
Bound ligand (Het Group name = FMN)
matches with 41.51% similarity
+ acceptor
= NAD(+)
+ reduced acceptor
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   3 terms 
  Biological process     oxidation-reduction process   4 terms 
  Biochemical function     electron carrier activity     16 terms  

 

 
    Added reference    
 
 
DOI no: 10.1038/nature11871 Nature 494:443-448 (2013)
PubMed id: 23417064  
 
 
Crystal structure of the entire respiratory complex I.
R.Baradaran, J.M.Berrisford, G.S.Minhas, L.A.Sazanov.
 
  ABSTRACT  
 
No abstract given.