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PDBsum entry 4h39

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protein ligands links
Transferase PDB id
4h39
Jmol
Contents
Protein chain
340 a.a.
Ligands
PRO-LYS-ARG-PRO-
THR-THR-LEU-ASN-
LEU-PHE
Waters ×154
PDB id:
4h39
Name: Transferase
Title: Crystal structure of jnk3 in complex with jip1 peptide
Structure: Mitogen-activated protein kinase 10. Chain: a. Fragment: catalytic domain (unp residues 46-400). Synonym: map kinase 10, mapk 10, map kinase p49 3f12, stres activated protein kinase 1b, sapk1b, stress-activated prote jnk3, c-jun n-terminal kinase 3. Engineered: yes. C-jun-amino-terminal kinase-interacting protein 1 chain: b.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jnk3, jnk3a, mapk10, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Resolution:
1.99Å     R-factor:   0.211     R-free:   0.239
Authors: J.C.Nwachukwu,J.D.Laughlin,M.Figuera-Losada,L.Cherry,K.W.Net P.V.Lograsso
Key ref: J.D.Laughlin et al. (2012). Structural mechanisms of allostery and autoinhibition in JNK family kinases. Structure, 20, 2174-2184. PubMed id: 23142346 DOI: 10.1016/j.str.2012.09.021
Date:
13-Sep-12     Release date:   21-Nov-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P53779  (MK10_HUMAN) -  Mitogen-activated protein kinase 10
Seq:
Struc:
464 a.a.
340 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.24  - Mitogen-activated protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+
protein
Bound ligand (Het Group name = PRO)
matches with 50.00% similarity
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     protein phosphorylation   1 term 
  Biochemical function     transferase activity, transferring phosphorus-containing groups     5 terms  

 

 
    reference    
 
 
DOI no: 10.1016/j.str.2012.09.021 Structure 20:2174-2184 (2012)
PubMed id: 23142346  
 
 
Structural mechanisms of allostery and autoinhibition in JNK family kinases.
J.D.Laughlin, J.C.Nwachukwu, M.Figuera-Losada, L.Cherry, K.W.Nettles, P.V.LoGrasso.
 
  ABSTRACT  
 
No abstract given.