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PDBsum entry 4g7s

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protein ligands metals Protein-protein interface(s) links
Oxidoreductase PDB id
4g7s
Jmol
Contents
Protein chains
554 a.a.
166 a.a.
31 a.a.
Ligands
HEM
HAS-PER
OLC ×15
CUA
Metals
_CU
Waters ×179
PDB id:
4g7s
Name: Oxidoreductase
Title: Structure of recombinant cytochrome ba3 oxidase mutant v236i thermus thermophilus
Structure: CytochromE C oxidase subunit 1. Chain: a. Synonym: cytochromE C ba(3) subunit i, cytochromE C oxidase polypeptide i, cytochrome cba3 subunit 1. Engineered: yes. Mutation: yes. CytochromE C oxidase subunit 2. Chain: b. Synonym: cytochromE C ba(3) subunit ii, cytochromE C oxidas
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8 / atcc 27634 / dsm 579. Gene: cbaa, ttha1135. Expressed in: thermus thermophilus. Expression_system_taxid: 274. Gene: cbab, ctac, ttha1134. Gene: cbad, ttha1133.
Resolution:
2.00Å     R-factor:   0.183     R-free:   0.207
Authors: Y.Li,Y.Chen,C.D.Stout
Key ref: Y.Li et al. Structure of recombinant cytochrome ba3 oxidase mutan from thermus thermophilus. To be published, .
Date:
20-Jul-12     Release date:   24-Jul-13    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q5SJ79  (COX1_THET8) -  Cytochrome c oxidase subunit 1
Seq:
Struc:
 
Seq:
Struc:
562 a.a.
554 a.a.*
Protein chain
Pfam   ArchSchema ?
Q5SJ80  (COX2_THET8) -  Cytochrome c oxidase subunit 2
Seq:
Struc:
168 a.a.
166 a.a.
Protein chain
Pfam   ArchSchema ?
P82543  (COXA_THET8) -  Cytochrome c oxidase polypeptide 2A
Seq:
Struc:
34 a.a.
31 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chains A, B, C: E.C.1.9.3.1  - Cytochrome-c oxidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O
4 × ferrocytochrome c
Bound ligand (Het Group name = HEM)
matches with 63.64% similarity
+
O(2)
Bound ligand (Het Group name = PER)
corresponds exactly
+ 4 × H(+)
= 4 × ferricytochrome c
+ 2 × H(2)O
      Cofactor: Copper
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   4 terms 
  Biological process     oxidation-reduction process   12 terms 
  Biochemical function     electron carrier activity     7 terms