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PDBsum entry 4g29

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Protein binding PDB id
4g29
Jmol
Contents
Protein chain
166 a.a.
Waters ×137
PDB id:
4g29
Name: Protein binding
Title: Structure of the catalytic domain of the salmonella virulenc ssei
Structure: Secreted effector protein ssei. Chain: a. Fragment: unp residues 137-322. Engineered: yes
Source: Salmonella enterica subsp. Enterica se typhimurium. Organism_taxid: 99287. Strain: lt2 / sgsc1412 / atcc 700720. Gene: ssei, srfh, stm1051
Resolution:
1.70Å     R-factor:   0.185     R-free:   0.214
Authors: C.E.Stebbins,S.S.Bhaskaran
Key ref: S.S.Bhaskaran and C.E.Stebbins (2012). Structure of the catalytic domain of the Salmonella virulence factor SseI. Acta Crystallogr D Biol Crystallogr, 68, 1613-1621. PubMed id: 23151626
Date:
11-Jul-12     Release date:   28-Nov-12    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q8ZQ79  (SSEI_SALTY) -  Secreted effector protein SseI
Seq:
Struc:
322 a.a.
166 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 

 
Acta Crystallogr D Biol Crystallogr 68:1613-1621 (2012)
PubMed id: 23151626  
 
 
Structure of the catalytic domain of the Salmonella virulence factor SseI.
S.S.Bhaskaran, C.E.Stebbins.
 
  ABSTRACT  
 
SseI is secreted into host cells by Salmonella and contributes to the establishment of systemic infections. The crystal structure of the C-terminal domain of SseI has been solved to 1.70 Å resolution, revealing it to be a member of the cysteine protease superfamily with a catalytic triad consisting of Cys178, His216 and Asp231 that is critical to its virulence activities. Structure-based analysis revealed that SseI is likely to possess either acyl hydrolase or acyltransferase activity, placing this virulence factor in the rapidly growing class of enzymes of this family utilized by bacterial pathogens inside eukaryotic cells.