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PDBsum entry 4fx3

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protein ligands Protein-protein interface(s) links
Transferase/transferase inhibitor PDB id
4fx3
Jmol
Contents
Protein chains
298 a.a.
257 a.a.
Ligands
60K ×2
DTT ×3
Waters ×154
PDB id:
4fx3
Name: Transferase/transferase inhibitor
Title: Crystal structure of the cdk2/cyclin a complex with oxindole
Structure: Cyclin-dependent kinase 2. Chain: a, c. Synonym: cell division protein kinase 2, p33 protein kinase engineered: yes. Cyclin-a2. Chain: b, d. Fragment: unp residues 175-432. Synonym: cyclin-a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: high-five. Gene: ccn1, ccna, ccna2, cyclin a.
Resolution:
2.75Å     R-factor:   0.192     R-free:   0.240
Authors: Y.N.Kang,J.A.Stuckey
Key ref: Y.N.Kang and j.a.stuckey Crystal structure of the cdk2/cyclin a complex with o inhibitor. To be published, .
Date:
02-Jul-12     Release date:   15-May-13    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2
Seq:
Struc:
298 a.a.
298 a.a.
Protein chains
Pfam   ArchSchema ?
P20248  (CCNA2_HUMAN) -  Cyclin-A2
Seq:
Struc:
432 a.a.
257 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, C: E.C.2.7.11.22  - Cyclin-dependent kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cyclin-dependent protein kinase holoenzyme complex   15 terms 
  Biological process     regulation of gene silencing   30 terms 
  Biochemical function     nucleotide binding     13 terms