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PDBsum entry 4fvo

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protein ligands metals links
Lyase/lyase inhibitor PDB id
4fvo
Jmol
Contents
Protein chain
257 a.a.
Ligands
MBO
0VV ×2
GOL
DMS
Metals
_ZN
Waters ×294
PDB id:
4fvo
Name: Lyase/lyase inhibitor
Title: Carbonic anhydrase ii in complex with n-[(2e)-3,4-dihydroqui 2(1h)-ylidene]sulfuric diamide
Structure: Carbonic anhydrase 2. Chain: a. Synonym: carbonate dehydratase ii, carbonic anhydrasE C, ca carbonic anhydrase ii, ca-ii. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.05Å     R-factor:   0.141     R-free:   0.170
Authors: A.Di Pizio,A.Heine,G.Klebe
Key ref: A.Di pizio et al. High resolution crystal structures of carbonic anhydr in complex with novel sulfamide binders. To be published, .
Date:
29-Jun-12     Release date:   03-Jul-13    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
257 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zn(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   11 terms 
  Biological process     angiotensin-mediated signaling pathway   22 terms 
  Biochemical function     protein binding     5 terms