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PDBsum entry 4f70

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protein ligands Protein-protein interface(s) links
Transferase/transcription/inhibitor PDB id
4f70
Jmol
Contents
Protein chains
327 a.a.
266 a.a.
Ligands
0ST
EDO
Waters ×32
PDB id:
4f70
Name: Transferase/transcription/inhibitor
Title: Crystal structure of human cdk8/cycc in complex with compoun tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[2-(morpho ethyl]urea)
Structure: Cyclin-dependent kinase 8. Chain: a. Fragment: unp residues 1-403. Synonym: cell division protein kinase 8, mediator complex s cdk8, mediator of RNA polymerase ii transcription subunit c protein kinase k35. Engineered: yes. Cyclin-c. Chain: b.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.
Resolution:
3.00Å     R-factor:   0.204     R-free:   0.239
Authors: E.V.Schneider,J.Boettcher,R.Huber,K.Maskos
Key ref: E.V.Schneider et al. The discovery of slowness in terms of compound bindin kinetics: a structure-Kinetic-Relationship study on cdk8/cycc. To be published, .
Date:
15-May-12     Release date:   01-May-13    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P49336  (CDK8_HUMAN) -  Cyclin-dependent kinase 8
Seq:
Struc:
464 a.a.
327 a.a.
Protein chain
Pfam   ArchSchema ?
P24863  (CCNC_HUMAN) -  Cyclin-C
Seq:
Struc:
283 a.a.
266 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class 1: Chain A: E.C.2.7.11.22  - Cyclin-dependent kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
   Enzyme class 2: Chain A: E.C.2.7.11.23  - [RNA-polymerase]-subunit kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
ATP
+ [DNA-directed RNA polymerase]
= ADP
+ [DNA-directed RNA polymerase] phosphate
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   4 terms 
  Biological process     gene expression   10 terms 
  Biochemical function     protein binding     6 terms