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PDBsum entry 4f4f

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protein ligands Protein-protein interface(s) links
Lyase PDB id
4f4f
Jmol
Contents
Protein chains
464 a.a.
Ligands
PLP ×2
Waters ×569
PDB id:
4f4f
Name: Lyase
Title: X-ray crystal structure of plp bound threonine synthase from melitensis
Structure: Threonine synthase. Chain: a, b. Engineered: yes
Source: Brucella melitensis bv. 1. Organism_taxid: 224914. Strain: 16m. Gene: bmei1450, bawg_0773. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.90Å     R-factor:   0.177     R-free:   0.206
Authors: Seattle Structural Genomics Center For Infectiuos Diseases
Key ref: J.S.Christensen et al. X-Ray crystal structure of plp bound threonine syntha brucella melitensis. To be published, .
Date:
10-May-12     Release date:   27-Jun-12    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q8YFS0  (Q8YFS0_BRUME) -  Threonine synthase
Seq:
Struc:
463 a.a.
464 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.3.1  - Threonine synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Threonine Biosynthesis
      Reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate
O-phospho-L-homoserine
+ H(2)O
= L-threonine
+ phosphate
      Cofactor: Pyridoxal 5'-phosphate
Pyridoxal 5'-phosphate
Bound ligand (Het Group name = PLP) matches with 93.75% similarity
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     cellular amino acid metabolic process   1 term 
  Biochemical function     lyase activity     3 terms