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PDBsum entry 4ez7

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protein ligands links
Transferase/antibiotic PDB id
4ez7
Jmol
Contents
Protein chain
302 a.a.
Ligands
STU
2AN ×2
EDO ×4
Waters ×40
PDB id:
4ez7
Name: Transferase/antibiotic
Title: Cdk2 in complex with staurosporine and 2 molecules of 8-anil naphthalene sulfonic acid
Structure: Cyclin-dependent kinase 2. Chain: a. Synonym: cdk2, cell division protein kinase 2, p33 protein engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.49Å     R-factor:   0.220     R-free:   0.274
Authors: R.Alam,M.P.Martin,J.-Y.Zhu,E.Schonbrunn
Key ref: M.P.Martin et al. (2012). A novel approach to the discovery of small-molecule ligands of CDK2. Chembiochem, 13, 2128-2136. PubMed id: 22893598
Date:
02-May-12     Release date:   22-Aug-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2
Seq:
Struc:
298 a.a.
302 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.22  - Cyclin-dependent kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cyclin-dependent protein kinase holoenzyme complex   15 terms 
  Biological process     regulation of gene silencing   27 terms 
  Biochemical function     nucleotide binding     12 terms  

 

 
    reference    
 
 
Chembiochem 13:2128-2136 (2012)
PubMed id: 22893598  
 
 
A novel approach to the discovery of small-molecule ligands of CDK2.
M.P.Martin, R.Alam, S.Betzi, D.J.Ingles, J.Y.Zhu, E.Schönbrunn.
 
  ABSTRACT  
 
No abstract given.