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PDBsum entry 4ewq

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protein ligands metals links
Transferase/transferase inhibitor PDB id
4ewq
Jmol
Contents
Protein chain
347 a.a.
Ligands
GG5
MWL ×2
BME
GOL
ACT
PEG
Metals
_ZN
_CL
Waters ×127
PDB id:
4ewq
Name: Transferase/transferase inhibitor
Title: Human p38 alpha mapk in complex with a pyridazine based inhi
Structure: Mitogen-activated protein kinase 14. Chain: a. Fragment: mitogen-activated protein kinase 14. Synonym: map kinase 14, mapk 14, cytokine suppressive anti- inflammatory drug-binding protein, csaid-binding protein, c kinase mxi2, max-interacting protein 2, mitogen-activated p kinase p38 alpha, map kinase p38 alpha, stress-activated pr kinase 2a, sapk2a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.10Å     R-factor:   0.182     R-free:   0.229
Authors: V.Grum-Tokars,G.Minasov,S.Roy,J.Schavocky,J Winsor,D.M.Watte W.F.Anderson,Center For Structural Genomics Of Infectious D (Csgid)
Key ref: V.Grum-Tokars et al. Human p38 alpha map kinase in complex with a pyridazi based inhibitor. To be published, .
Date:
27-Apr-12     Release date:   27-Jun-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q16539  (MK14_HUMAN) -  Mitogen-activated protein kinase 14
Seq:
Struc:
360 a.a.
347 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.24  - Mitogen-activated protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cell   8 terms 
  Biological process     intracellular signal transduction   71 terms 
  Biochemical function     nucleotide binding     11 terms