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PDBsum entry 4en2

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protein Protein-protein interface(s) links
Viral protein/immune system PDB id
4en2
Jmol
Contents
Protein chains
256 a.a.
149 a.a.
133 a.a.
12 a.a.
18 a.a.
Waters ×54
PDB id:
4en2
Name: Viral protein/immune system
Title: HIV-1 nef in complex with mhc-i cytoplasmic domain and mu1 a subunit of ap1 adaptor (second domain)
Structure: Ap-1 complex subunit mu-1. Chain: m, a. Fragment: sorting motif recognition domain. Synonym: ap-mu chain family member mu1a, adaptor protein co mu-1 subunit, adaptor-related protein complex 1 mu-1 subuni clathrin assembly protein complex 1 medium chain 1, clathri assembly protein ap47, clathrin coat-associated protein ap4 adaptor ha1/ap1 adaptin mu-1 subunit, mu-adaptin 1, mu1a-ad engineered: yes.
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: ap1m1, cltnm. Expressed in: escherichia coli. Expression_system_taxid: 562. Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: nl-43.
Resolution:
2.58Å     R-factor:   0.210     R-free:   0.258
Authors: X.Jia,Y.Xiong
Key ref: X.Jia et al. (2012). Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef. Nat Struct Mol Biol, 19, 701-706. PubMed id: 22705789
Date:
12-Apr-12     Release date:   20-Jun-12    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P35585  (AP1M1_MOUSE) -  AP-1 complex subunit mu-1
Seq:
Struc:
423 a.a.
256 a.a.
Protein chain
Pfam   ArchSchema ?
Q90VU7  (Q90VU7_9HIV1) -  Protein Nef
Seq:
Struc:
206 a.a.
149 a.a.
Protein chain
Pfam   ArchSchema ?
Q90VU7  (Q90VU7_9HIV1) -  Protein Nef
Seq:
Struc:
206 a.a.
133 a.a.
Protein chain
Pfam   ArchSchema ?
P01892  (1A02_HUMAN) -  HLA class I histocompatibility antigen, A-2 alpha chain
Seq:
Struc:
365 a.a.
12 a.a.*
Protein chain
Pfam   ArchSchema ?
P01892  (1A02_HUMAN) -  HLA class I histocompatibility antigen, A-2 alpha chain
Seq:
Struc:
365 a.a.
18 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   5 terms 
  Biological process     viral reproduction   12 terms 
  Biochemical function     protein binding     10 terms  

 

 
Nat Struct Mol Biol 19:701-706 (2012)
PubMed id: 22705789  
 
 
Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef.
X.Jia, R.Singh, S.Homann, H.Yang, J.Guatelli, Y.Xiong.
 
  ABSTRACT  
 
No abstract given.