spacer
spacer

PDBsum entry 4eh2

Go to PDB code: 
protein ligands links
Transferase/transferase inhibitor PDB id
4eh2
Jmol
Contents
Protein chain
337 a.a.
Ligands
IRG
0OK
Waters ×104
PDB id:
4eh2
Name: Transferase/transferase inhibitor
Title: Human p38 map kinase in complex with np-f1 and rl87
Structure: Mitogen-activated protein kinase 14. Chain: a. Synonym: map kinase 14, mapk 14, cytokine suppressive anti- inflammatory drug-binding protein, csaid-binding protein, c kinase mxi2, max-interacting protein 2, mitogen-activated p kinase p38 alpha, map kinase p38 alpha, stress-activated pr kinase 2a, sapk2a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
2.00Å     R-factor:   0.226     R-free:   0.274
Authors: B.Over,C.Gruetter,H.Waldmann,D.Rauh
Key ref: B.Over et al. (2013). Natural-product-derived fragments for fragment-based ligand discovery. Nat Chem, 5, 21-28. PubMed id: 23247173 DOI: 10.1038/nchem.1506
Date:
02-Apr-12     Release date:   05-Dec-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q16539  (MK14_HUMAN) -  Mitogen-activated protein kinase 14
Seq:
Struc:
360 a.a.
337 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.24  - Mitogen-activated protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cell   8 terms 
  Biological process     intracellular signal transduction   71 terms 
  Biochemical function     nucleotide binding     11 terms  

 

 
    reference    
 
 
DOI no: 10.1038/nchem.1506 Nat Chem 5:21-28 (2013)
PubMed id: 23247173  
 
 
Natural-product-derived fragments for fragment-based ligand discovery.
B.Over, S.Wetzel, C.Grütter, Y.Nakai, S.Renner, D.Rauh, H.Waldmann.
 
  ABSTRACT  
 
No abstract given.