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PDBsum entry 4e41

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protein metals Protein-protein interface(s) links
Immune system PDB id
4e41
Jmol
Contents
Protein chains
179 a.a.
179 a.a.
15 a.a.
181 a.a.
236 a.a.
190 a.a.
Metals
_NA ×2
Waters ×172
PDB id:
4e41
Name: Immune system
Title: Structural basis for the recognition of mutant self by a tum specific, mhc class ii-restricted t cell receptor g4
Structure: Hla class ii histocompatibility antigen, dr alpha chain: a, f. Fragment: unp residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 b chain: b, g. Fragment: unp residues 30-219. Synonym: mhc class ii antigen drb1 1, Dr-1, dr1.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra, hla-dra1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: hla-drb1. Gene: tpi1, tpi. Expression_system_taxid: 562
Resolution:
2.60Å     R-factor:   0.201     R-free:   0.264
Authors: L.Deng,R.J.Langley,Q.Wang,S.L.Topalian,R.A.Mariuzza
Key ref: Lg et al. Stuturaral basis for the recognition of mutant self b t-S-Spepecific, Mhc class ii-Restricted t cell recept. Pnanatltl.Acad.Sci.Usa, .
Date:
11-Mar-12     Release date:   29-Aug-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P01903  (DRA_HUMAN) -  HLA class II histocompatibility antigen, DR alpha chain
Seq:
Struc:
254 a.a.
179 a.a.
Protein chains
Pfam   ArchSchema ?
P04229  (2B11_HUMAN) -  HLA class II histocompatibility antigen, DRB1-1 beta chain
Seq:
Struc:
266 a.a.
179 a.a.
Protein chains
No UniProt id for this chain
Struc: 15 a.a.
Protein chain
No UniProt id for this chain
Struc: 181 a.a.
Protein chains
No UniProt id for this chain
Struc: 236 a.a.
Protein chain
No UniProt id for this chain
Struc: 190 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains F, H: E.C.5.3.1.1  - Triose-phosphate isomerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate
D-glyceraldehyde 3-phosphate
= glycerone phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   2 terms 
  Biological process     immune response   2 terms