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PDBsum entry 4e3d

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protein ligands metals links
Lyase/lyase inhibitor PDB id
4e3d
Jmol
Contents
Protein chain
257 a.a.
Ligands
MBO
GTQ ×2
GOL
Metals
_ZN
Waters ×178
PDB id:
4e3d
Name: Lyase/lyase inhibitor
Title: Nucleophile recognition as an alternative inhibition mode fo acid based carbonic anhydrase inhibitors
Structure: Carbonic anhydrase 2. Chain: a. Synonym: carbonate dehydratase ii, carbonic anhydrasE C, ca carbonic anhydrase ii, ca-ii. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.60Å     R-factor:   0.171     R-free:   0.211
Authors: S.M.Cohen
Key ref: D.P.Martin and S.M.Cohen (2012). Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors. Chem Commun (Camb), 48, 5259-5261. PubMed id: 22531842 DOI: 10.1039/c2cc32013d
Date:
09-Mar-12     Release date:   27-Jun-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
257 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zn(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   11 terms 
  Biological process     angiotensin-mediated signaling pathway   21 terms 
  Biochemical function     protein binding     5 terms  

 

 
    Added reference    
 
 
DOI no: 10.1039/c2cc32013d Chem Commun (Camb) 48:5259-5261 (2012)
PubMed id: 22531842  
 
 
Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors.
D.P.Martin, S.M.Cohen.
 
  ABSTRACT  
 
No abstract given.