spacer
spacer

PDBsum entry 4e1a

Go to PDB code: 
protein ligands links
Transferase PDB id
4e1a
Jmol
Contents
Protein chain
157 a.a.
Ligands
GOL
Waters ×103
PDB id:
4e1a
Name: Transferase
Title: Phosphopantetheine adenylyltransferase from mycobacterium tu at 1.62a resolution
Structure: Phosphopantetheine adenylyltransferase. Chain: a. Synonym: dephospho-coa pyrophosphorylase, pantetheine-phosp adenylyltransferase, ppat. Engineered: yes
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: coad, kdtb, rv2965c, mt3043, mtcy349.22, u0002e. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.62Å     R-factor:   0.173     R-free:   0.215
Authors: V.I.Timofeev,E.A.Smirnova,L.A.Chupova,R.S.Esipov,I.P.Kuranov
Key ref: V.Timofeev et al. (2012). X-ray study of the conformational changes in the molecule of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis during the catalyzed reaction. Acta Crystallogr D Biol Crystallogr, 68, 1660-1670. PubMed id: 23151631 DOI: 10.1107/S0907444912040206
Date:
06-Mar-12     Release date:   21-Nov-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam  
P9WPA5  (COAD_MYCTU) -  Phosphopantetheine adenylyltransferase
Seq:
Struc:
161 a.a.
157 a.a.
Key:    Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.7.3  - Pantetheine-phosphate adenylyltransferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Coenzyme A Biosynthesis (late stages)
      Reaction: ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA
ATP
+ pantetheine 4'-phosphate
= diphosphate
+ 3'-dephospho-CoA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   1 term 
  Biological process     biosynthetic process   2 terms 
  Biochemical function     catalytic activity     6 terms  

 

 
    reference    
 
 
DOI no: 10.1107/S0907444912040206 Acta Crystallogr D Biol Crystallogr 68:1660-1670 (2012)
PubMed id: 23151631  
 
 
X-ray study of the conformational changes in the molecule of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis during the catalyzed reaction.
V.Timofeev, E.Smirnova, L.Chupova, R.Esipov, I.Kuranova.
 
  ABSTRACT  
 
No abstract given.