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PDBsum entry 4e02

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protein ligands metals links
Transferase/transferase inhibitor PDB id
4e02
Jmol
Contents
Protein chain
307 a.a.
Ligands
ANP
WJ1
Metals
_MG
__K
Waters ×157
PDB id:
4e02
Name: Transferase/transferase inhibitor
Title: Crystal structure of branched-chain alpha-ketoacid dehydroge kinase/(s)-2-chloro-3-phenylpropanoic acid complex with amp
Structure: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide mitochondrial. Chain: a. Synonym: branched-chain alpha-ketoacid dehydrogenase kinase kinase, bckdhkin. Engineered: yes
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: bckdk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.15Å     R-factor:   0.188     R-free:   0.211
Authors: S.C.Tso,J.L.Chuang,W.J.Gui,R.M.Wynn,J.Li,D.T.Chuang
Key ref: S.C.Tso et al. Structures of branched-Chain alpha-Ketoacid dehydroge kinase-Inhibitor complexes. To be published, .
Date:
02-Mar-12     Release date:   13-Mar-13    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q00972  (BCKD_RAT) -  [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
Seq:
Struc:
412 a.a.
307 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.4  - [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] = ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
ATP
+ [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)]
=
ADP
Bound ligand (Het Group name = ANP)
matches with 81.25% similarity
+ [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     mitochondrion   3 terms 
  Biological process     phosphorylation   3 terms 
  Biochemical function     nucleotide binding     8 terms