spacer
spacer

PDBsum entry 4dgc

Go to PDB code: 
protein Protein-protein interface(s) links
Isomerase/immunosuppressant PDB id
4dgc
Jmol
Contents
Protein chains
163 a.a.
11 a.a.
Waters ×272
PDB id:
4dgc
Name: Isomerase/immunosuppressant
Title: Trimcyp cyclophilin domain from macaca mulatta: cyclosporin
Structure: Trimcyp. Chain: a, b, c, d, e. Fragment: cyclophilin domain (unp residues 304-468). Synonym: peptidyl-prolyl cis-trans isomerase. Engineered: yes. Cyclosporin a. Chain: f, g, h, i, j. Engineered: yes
Source: Macaca mulatta. Rhesus macaque. Organism_taxid: 9544. Gene: trimcyp. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Tolypocladium inflatum. Organism_taxid: 29910
Resolution:
2.65Å     R-factor:   0.183     R-free:   0.216
Authors: M.E.C.Caines,K.Bichel,A.J.Price,W.A.Mcewan,L.C.James
Key ref: M.E.Caines et al. (2012). Diverse HIV viruses are targeted by a conformationally dynamic antiviral. Nat Struct Mol Biol, 19, 411-416. PubMed id: 22407016
Date:
25-Jan-12     Release date:   08-Feb-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P62940  (PPIA_MACMU) -  Peptidyl-prolyl cis-trans isomerase A
Seq:
Struc:
165 a.a.
163 a.a.*
Protein chains
No UniProt id for this chain
Struc: 11 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chains A, B, C, D, E: E.C.5.2.1.8  - Peptidylprolyl isomerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Peptidylproline (omega=180) = peptidylproline (omega=0)
Peptidylproline (omega=180)
= peptidylproline (omega=0)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   8 terms 
  Biological process     lipid particle organization   6 terms 
  Biochemical function     isomerase activity     4 terms  

 

 
    Added reference    
 
 
Nat Struct Mol Biol 19:411-416 (2012)
PubMed id: 22407016  
 
 
Diverse HIV viruses are targeted by a conformationally dynamic antiviral.
M.E.Caines, K.Bichel, A.J.Price, W.A.McEwan, G.J.Towers, B.J.Willett, S.M.Freund, L.C.James.
 
  ABSTRACT  
 
No abstract given.