PDBsum entry 4axx

Transferase

PDB id: 4axx

Contents

Protein chain

407 a.a.

Ligands

ADP

3PG-BEF

Metals

_MG

_CL

Waters ×423

PDB id:

4axx

Name:

Transferase

Title:

The catalytically active fully closed conformation of human phosphoglycerate kinase in complex with adp 3-phosphoglycerate and beryllium trifluoride

Structure:

Phosphoglycerate kinase 1. Chain: a. Synonym: cell migration-inducing gene 10 protein, primer recognition protein 2, prp 2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Resolution:

1.74Å R-factor: 0.172 R-free: 0.207

Authors:

M.W.Bowler

Key ref:

M.W.Bowler et al. Catalytic activity in the transitions state analogue stabilised conformation of a phosphoryl transfer enzy. To be published, . PubMed id: 39106858

Date:

15-Jun-12 Release date: 26-Jun-13

Protein chain

P00558  (PGK1_HUMAN) -  Phosphoglycerate kinase 1 from Homo sapiens

Seq: 417 a.a.

Struc: 407 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.2.3 - phosphoglycerate kinase.
• Pathway: Calvin Cycle (carbon fixation stages)
• Reaction: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP

(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP (Bound ligand (Het Group name = ADP) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site