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PDBsum entry 4au8

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protein ligands Protein-protein interface(s) links
Transferase PDB id
4au8
Jmol
Contents
Protein chains
276 a.a.
Ligands
SO4 ×6
Z3R ×2
IMD
Waters ×474
PDB id:
4au8
Name: Transferase
Title: Crystal structure of compound 4a in complex with cdk5, showing an unusual binding mode to the hinge region via a water molecule
Structure: Cyclin-dependent kinase 5. Chain: a, b. Fragment: residues 2-292. Synonym: cell division protein kinase 5, serine/threonine-p kinase pssalre, tau protein kinase ii catalytic subunit, t catalytic subunit. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Resolution:
1.90Å     R-factor:   0.197     R-free:   0.234
Authors: J.Malmstrom,J.Viklund,C.Slivo,A.Costa,M.Maudet,C.Sandelin,G. L.L.Olsson,A.Aagaard,S.Geschwindner,Y.Xue,M.Vasange
Date:
14-May-12     Release date:   27-Mar-13    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q00535  (CDK5_HUMAN) -  Cyclin-dependent kinase 5
Seq:
Struc:
292 a.a.
276 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.1  - Non-specific serine/threonine protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     synapse   20 terms 
  Biological process     protein localization to synapse   83 terms 
  Biochemical function     nucleotide binding     15 terms