Similar but different: thermodynamic and structural characterization of a pair of enantiomers binding to acetylcholinesterase.
Angew Chem Int Ed Engl,
PubMed id: 23161758
Take a closer look: Unexpectedly, a pair of enantiomeric ligands proved to have
similar binding affinities for acetylcholinesterase. Further studies indicated
that the enantiomers exhibit different thermodynamic profiles. Analyses of the
noncovalent interactions in the protein-ligand complexes revealed that these
differences are partly due to nonclassical hydrogen bonds between the ligands
and aromatic side chains of the protein.