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PDBsum entry 4a9y

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protein ligands links
Transferase PDB id
4a9y
Jmol
Contents
Protein chain
334 a.a.
Ligands
AQZ
Waters ×81
PDB id:
4a9y
Name: Transferase
Title: P38alpha map kinase bound to cmpd 8
Structure: Mitogen-activated protein kinase 14. Chain: a. Synonym: map kinase 14, mapk 14, cytokine suppressive anti-inflammatory drug-binding protein, csaid-binding prot csbp, map kinase mxi2, max-interacting protein 2, mitogen-activated protein kinase p38 alpha, map kinase p38 stress-activated protein kinase 2a, sapk2a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
2.20Å     R-factor:   0.219     R-free:   0.249
Authors: S.Gerhardt,D.Hargreaves
Key ref: D.S.Brown et al. (2012). The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases. Bioorg Med Chem Lett, 22, 3879-3883. PubMed id: 22608965 DOI: 10.1016/j.bmcl.2012.04.116
Date:
29-Nov-11     Release date:   16-May-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q16539  (MK14_HUMAN) -  Mitogen-activated protein kinase 14
Seq:
Struc:
360 a.a.
334 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.24  - Mitogen-activated protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cell   8 terms 
  Biological process     intracellular signal transduction   71 terms 
  Biochemical function     nucleotide binding     11 terms  

 

 
    reference    
 
 
DOI no: 10.1016/j.bmcl.2012.04.116 Bioorg Med Chem Lett 22:3879-3883 (2012)
PubMed id: 22608965  
 
 
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.
D.S.Brown, J.G.Cumming, P.Bethel, J.Finlayson, S.Gerhardt, I.Nash, R.A.Pauptit, K.G.Pike, A.Reid, W.Snelson, S.Swallow, C.Thompson.
 
  ABSTRACT  
 
No abstract given.