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PDBsum entry 4a7a

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protein ligands Protein-protein interface(s) links
Oxidoreductase PDB id
4a7a
Jmol
Contents
Protein chain
499 a.a.
Ligands
FAD ×2
RGZ ×2
Waters ×791
PDB id:
4a7a
Name: Oxidoreductase
Title: Crystal structure of human monoamine oxidase b (mao b) in complex with rosiglitazone
Structure: Amine oxidase [flavin-containing] b. Chain: a, b. Synonym: monoamine oxidase b, monoamine oxidase type b, mao engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Resolution:
1.70Å     R-factor:   0.186     R-free:   0.213
Authors: C.Binda,M.Aldeco,W.J.Geldenhuys,M.Tortorici,A.Mattevi,D.E.Ed
Key ref: C.Binda et al. (2011). Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs. ACS Med Chem Lett, 3, 39-42. PubMed id: 22282722
Date:
11-Nov-11     Release date:   25-Apr-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P27338  (AOFB_HUMAN) -  Amine oxidase [flavin-containing] B
Seq:
Struc:
 
Seq:
Struc:
520 a.a.
499 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.4.3.4  - Monoamine oxidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2
RCH(2)NHR'
+ H(2)O
+ O(2)
= RCHO
+ R'NH(2)
+ H(2)O(2)
      Cofactor: FAD
FAD
Bound ligand (Het Group name = FAD) corresponds exactly
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   6 terms 
  Biological process     small molecule metabolic process   14 terms 
  Biochemical function     electron carrier activity     5 terms  

 

 
    reference    
 
 
ACS Med Chem Lett 3:39-42 (2011)
PubMed id: 22282722  
 
 
Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs.
C.Binda, M.Aldeco, W.J.Geldenhuys, M.Tortorici, A.Mattevi, D.E.Edmondson.
 
  ABSTRACT  
 
No abstract given.