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PDBsum entry 4xcs
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Oxidoreductase
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PDB id
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4xcs
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PDB id:
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| Name: |
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Oxidoreductase
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Title:
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Human peroxiredoxin-1 c83s mutant
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Structure:
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Peroxiredoxin-1. Chain: a, b, c, d, e, f. Synonym: natural killer cell-enhancing factor a,nkef-a,proliferation- associated gene protein,pag,thioredoxin peroxidase 2,thioredoxin- dependent peroxide reductase 2. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: prdx1, paga, pagb, tdpx2. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.10Å
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R-factor:
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0.178
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R-free:
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0.222
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Authors:
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K.J.Cho,J.-H.Lee,T.G.Khan,Y.Park,A.Cho,T.-S.Chang,K.H.Kim
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Key ref:
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K.J.Cho
et al.
Human peroxiredoxin-1 c83s mutant.
To be published,
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Date:
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18-Dec-14
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Release date:
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13-Jan-16
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PROCHECK
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Headers
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References
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Q06830
(PRDX1_HUMAN) -
Peroxiredoxin-1 from Homo sapiens
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Seq:
Struc:
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199 a.a.
179 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.1.11.1.24
- thioredoxin-dependent peroxiredoxin.
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Reaction:
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a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]- disulfide + H2O
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hydroperoxide
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+
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[thioredoxin]-dithiol
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=
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alcohol
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+
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[thioredoxin]- disulfide
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+
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H2O
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
