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PDBsum entry 4i77

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protein Protein-protein interface(s) links
Immune system/cytokine PDB id
4i77
Jmol
Contents
Protein chains
219 a.a.
218 a.a.
97 a.a.
Waters ×378
PDB id:
4i77
Name: Immune system/cytokine
Title: Lebrikizumab fab bound to il-13
Structure: Lebrikizumab heavy chain. Chain: h. Fragment: fab. Engineered: yes. Lebrikizumab light chain. Chain: l. Fragment: fab. Engineered: yes. Interleukin-13.
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Human. Gene: il13, nc30. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.90Å     R-factor:   0.180     R-free:   0.219
Authors: C.Eigenbrot,M.Ultsch
Key ref: M.Ultsch et al. (2013). Structural basis of signaling blockade by anti-IL-13 antibody Lebrikizumab. J Mol Biol, 425, 1330-1339. PubMed id: 23357170 DOI: 10.1016/j.jmb.2013.01.024
Date:
30-Nov-12     Release date:   06-Feb-13    
PROCHECK
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 Headers
 References

Protein chain
No UniProt id for this chain
Struc: 219 a.a.
Protein chain
No UniProt id for this chain
Struc: 218 a.a.
Protein chain
Pfam   ArchSchema ?
P35225  (IL13_HUMAN) -  Interleukin-13
Seq:
Struc:
146 a.a.
97 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   4 terms 
  Biological process     cellular response to mechanical stimulus   25 terms 
  Biochemical function     protein binding     4 terms  

 

 
DOI no: 10.1016/j.jmb.2013.01.024 J Mol Biol 425:1330-1339 (2013)
PubMed id: 23357170  
 
 
Structural basis of signaling blockade by anti-IL-13 antibody Lebrikizumab.
M.Ultsch, J.Bevers, G.Nakamura, R.Vandlen, R.F.Kelley, L.C.Wu, C.Eigenbrot.
 
  ABSTRACT  
 
No abstract given.