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PDBsum entry 4grw

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protein ligands Protein-protein interface(s) links
Immune system PDB id
4grw
Jmol
Contents
Protein chains
130 a.a.
293 a.a.
129 a.a.
125 a.a.
125 a.a.
123 a.a.
Ligands
NAG-NAG-BMA-MAN-
MAN
×2
Waters ×710
PDB id:
4grw
Name: Immune system
Title: Structure of a complex of human il-23 with 3 nanobodies (lla
Structure: Interleukin-23 subunit alpha. Chain: a, c. Synonym: il-23 subunit alpha, il-23-a, interleukin-23 subun il-23p19. Engineered: yes. Interleukin-12 subunit beta. Chain: b, d. Synonym: il-12b, cytotoxic lymphocyte maturation factor 40 subunit, clmf p40, il-12 subunit p40, nk cell stimulatory f
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: il23 p19, il23a, sgrf, unq2498/pro5798. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: il12 p40, il12b, nksf2. Lama glama. Organism_taxid: 9844.
Resolution:
2.55Å     R-factor:   0.184     R-free:   0.218
Authors: A.Desmyter,S.Spinelli,C.Button,M.Saunders,H.De Haard,H.Romme A.Union,C.Cambillau
Key ref: A.Desmyter et al. Potent multitopic nanobody inhibitors of the chronic inflammation promoting cytokine hil23.. To be published, .
Date:
27-Aug-12     Release date:   19-Feb-14    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q9NPF7  (IL23A_HUMAN) -  Interleukin-23 subunit alpha
Seq:
Struc:
189 a.a.
130 a.a.
Protein chains
Pfam   ArchSchema ?
P29460  (IL12B_HUMAN) -  Interleukin-12 subunit beta
Seq:
Struc:
328 a.a.
293 a.a.
Protein chain
Pfam   ArchSchema ?
Q9NPF7  (IL23A_HUMAN) -  Interleukin-23 subunit alpha
Seq:
Struc:
189 a.a.
129 a.a.
Protein chains
No UniProt id for this chain
Struc: 125 a.a.
Protein chains
No UniProt id for this chain
Struc: 125 a.a.
Protein chains
No UniProt id for this chain
Struc: 123 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   2 terms 
  Biological process     immune response   1 term 
  Biochemical function     cytokine activity     2 terms