PDBsum entry 4dei

Transferase/transferase inhibitor

PDB id: 4dei

Contents

Protein chain

287 a.a.

Ligands

0JL

Waters ×167

PDB id:

4dei

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of c-met in complex with triazolopyridinone inhibitor 24

Structure:

Hepatocyte growth factor receptor. Chain: a. Synonym: hgf receptor, hgf/sf receptor, proto-oncogenE C-met, scatter factor receptor, sf receptor, tyrosine-protein kinase met. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.

Resolution:

2.05Å R-factor: 0.224 R-free: 0.289

Authors:

D.A.Whittington,A.M.Long

Key ref:

C.M.Bode et al. (2012). Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors. Bioorg Med Chem Lett, 22, 4089-4093. PubMed id: 22595176

Date:

20-Jan-12 Release date: 30-May-12

Protein chain

P08581  (MET_HUMAN) -  Hepatocyte growth factor receptor from Homo sapiens

Seq: 1390 a.a.

Struc: 287 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Bioorg Med Chem Lett 22:4089-4093 (2012)

PubMed id: 22595176

Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.

C.M.Bode, A.A.Boezio, B.K.Albrecht, S.F.Bellon, L.Berry, M.A.Broome, D.Choquette, I.Dussault, R.T.Lewis, M.H.Lin, K.Rex, D.A.Whittington, Y.Yang, J.C.Harmange.

ABSTRACT

No abstract given.