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PDBsum entry 4ah2

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protein ligands Protein-protein interface(s) links
Immune system PDB id
4ah2
Jmol
Contents
Protein chains
177 a.a.
198 a.a.
Ligands
GOL ×4
Waters ×220
PDB id:
4ah2
Name: Immune system
Title: Hla-dr1 with covalently linked clip106-120 in canonical orie
Structure: Hla class ii histocompatibility antigen, dr alpha chain: a. Fragment: extracellular domain, residues 26-217. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen gamma cha class ii histocompatibility antigen\,drb1-1 beta chain. Chain: b. Fragment: extracellular domain, residues 106-120,30-227.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Homo sapiens, homo sapiens. Human, human. Organism_taxid: 9606, 9606.
Resolution:
2.36Å     R-factor:   0.193     R-free:   0.240
Authors: A.Schlundt,S.Guenther,J.Sticht,M.Wieczorek,Y.Roske,U.Heinema C.Freund
Key ref: A.Schlundt et al. (2012). Peptide linkage to the α-subunit of MHCII creates a stably inverted antigen presentation complex. J Mol Biol, 423, 294-302. PubMed id: 22820093 DOI: 10.1016/j.jmb.2012.07.008
Date:
03-Feb-12     Release date:   01-Aug-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P01903  (DRA_HUMAN) -  HLA class II histocompatibility antigen, DR alpha chain
Seq:
Struc:
254 a.a.
177 a.a.
Protein chain
Pfam   ArchSchema ?
P04229  (2B11_HUMAN) -  HLA class II histocompatibility antigen, DRB1-1 beta chain
Seq:
Struc:
266 a.a.
198 a.a.*
Protein chain
Pfam   ArchSchema ?
P04233  (HG2A_HUMAN) -  HLA class II histocompatibility antigen gamma chain
Seq:
Struc:
296 a.a.
198 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 179 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   2 terms 
  Biological process     immune response   2 terms 

 

 
DOI no: 10.1016/j.jmb.2012.07.008 J Mol Biol 423:294-302 (2012)
PubMed id: 22820093  
 
 
Peptide linkage to the α-subunit of MHCII creates a stably inverted antigen presentation complex.
A.Schlundt, S.Günther, J.Sticht, M.Wieczorek, Y.Roske, U.Heinemann, C.Freund.
 
  ABSTRACT  
 
No abstract given.