spacer
spacer

PDBsum entry 3zv2

Go to PDB code: 
protein links
Hydrolase PDB id
3zv2
Jmol
Contents
Protein chain
281 a.a.
PDB id:
3zv2
Name: Hydrolase
Title: Human protein-tyrosine phosphatase 1b c215a, s216a mutant
Structure: Tyrosine-protein phosphatase non-receptor type 1. Chain: a. Fragment: residues 1-320. Synonym: protein-tyrosine phosphatase 1b, ptp-1b. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606
Resolution:
2.80Å     R-factor:   0.210     R-free:   0.267
Authors: D.Barford,A.Salmeen,N.K.Tonks
Key ref: A.Haque et al. (2011). Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity. Cell, 147, 185-198. PubMed id: 21962515 DOI: 10.1016/j.cell.2011.08.036
Date:
22-Jul-11     Release date:   31-Aug-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P18031  (PTN1_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 1
Seq:
Struc:
435 a.a.
281 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
= protein tyrosine
+ phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     dephosphorylation   2 terms 
  Biochemical function     phosphatase activity     2 terms  

 

 
    reference    
 
 
DOI no: 10.1016/j.cell.2011.08.036 Cell 147:185-198 (2011)
PubMed id: 21962515  
 
 
Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity.
A.Haque, J.N.Andersen, A.Salmeen, D.Barford, N.K.Tonks.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
22743979 A.D.Lawson (2012).
Antibody-enabled small-molecule drug discovery.
  Nat Rev Drug Discov, 11, 519-525.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.