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PDBsum entry 3zsg

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protein ligands links
Transferase PDB id
3zsg
Jmol
Contents
Protein chain
337 a.a.
Ligands
T75
BOG
Waters ×317
PDB id:
3zsg
Name: Transferase
Title: X-ray structure of p38alpha bound to tak-715
Structure: Mitogen-activated protein kinase 14. Chain: a. Synonym: map kinase 14, mapk 14, cytokine suppressive anti-inflammatory drug-binding protein, csaid-binding prot csbp, map kinase mxi2, max-interacting protein 2, mitogen-activated protein kinase p38 alpha, map kinase p38 sapk2a, p38a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.
Resolution:
1.89Å     R-factor:   0.191     R-free:   0.232
Authors: R.Azevedo,M.Van Zeeland,H.Raaijmakers,B.Kazemier,A.Oubrie
Key ref: R.Azevedo et al. (2012). X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitors. Acta Crystallogr D Biol Crystallogr, 68, 1041-1050. PubMed id: 22868770 DOI: 10.1107/S090744491201997X
Date:
28-Jun-11     Release date:   13-Jun-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q16539  (MK14_HUMAN) -  Mitogen-activated protein kinase 14
Seq:
Struc:
360 a.a.
337 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.24  - Mitogen-activated protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cell   8 terms 
  Biological process     intracellular signal transduction   71 terms 
  Biochemical function     nucleotide binding     11 terms  

 

 
    reference    
 
 
DOI no: 10.1107/S090744491201997X Acta Crystallogr D Biol Crystallogr 68:1041-1050 (2012)
PubMed id: 22868770  
 
 
X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitors.
R.Azevedo, M.van Zeeland, H.Raaijmakers, B.Kazemier, J.de Vlieg, A.Oubrie.
 
  ABSTRACT  
 
No abstract given.