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PDBsum entry 3zs4

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protein ligands links
Isomerase PDB id
3zs4
Jmol
Contents
Protein chain
244 a.a.
Ligands
1PR
Waters ×271
PDB id:
3zs4
Name: Isomerase
Title: Crystal structure of mycobacterium tuberculosis phosphoribos isomerase with bound prfar
Structure: Phosphoribosyl isomerase a. Chain: a. Synonym: phosphoribosylformimino-5-aminoimidazole carboxami ribotide isomerase, pria isomerase, prai, 1-(5-phosphoribo [(5-phosphoribosylamino)methylideneamino] imidazole-4-carb isomerase, n-(5'-phosphoribosyl)anthranilate isomerase. Engineered: yes
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: ril.
Resolution:
1.90Å     R-factor:   0.176     R-free:   0.213
Authors: A.V.Due,J.Kuper,A.Geerlof,M.Wilmanns
Key ref: A.V.Due et al. Crystal structure of mycobacterium tuberculosis phosphoribosyl isomerase with bound prfar. To be published, .
Date:
22-Jun-11     Release date:   11-Jul-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam  
P9WMM5  (HIS4_MYCTU) -  Phosphoribosyl isomerase A
Seq:
Struc:
244 a.a.
244 a.a.
Key:    Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class 2: E.C.5.3.1.16  - 1-(5-phosphoribosyl)-5-
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Histidine Biosynthesis (early stages)
      Reaction: 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D- ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1- deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide
   Enzyme class 3: E.C.5.3.1.24  - Phosphoribosylanthranilate isomerase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
      Reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1- deoxy-D-ribulose 5-phosphate
N-(5-phospho-beta-D-ribosyl)anthranilate
= 1-(2-carboxyphenylamino)-1- deoxy-D-ribulose 5-phosphate
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   1 term 
  Biological process     metabolic process   5 terms 
  Biochemical function     catalytic activity     4 terms