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PDBsum entry 3zqz

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protein ligands metals links
Hydrolase PDB id
3zqz
Jmol
Contents
Protein chain
596 a.a.
Ligands
NAG-NAG-BMA-MAN
NAG ×2
MAN-BMA
SLC
Metals
_ZN
Waters ×201
PDB id:
3zqz
Name: Hydrolase
Title: Crystal structure of ance in complex with a selenium analogu captopril
Structure: Angiotensin-converting enzyme. Chain: a. Fragment: residues 17-614. Synonym: dipeptidyl carboxypeptidase i, kininase ii, ance. Engineered: yes
Source: Drosophila melanogaster. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 644223.
Resolution:
2.35Å     R-factor:   0.205     R-free:   0.237
Authors: M.Akif,G.Masuyer,S.L.U.Schwager,B.J.Bhuyan,G.Mugesh,R.E.Isaa E.D.Sturrock,K.R.Acharya
Key ref: M.Akif et al. (2011). Structural characterization of angiotensin I-converting enzyme in complex with a selenium analogue of captopril. FEBS J, 278, 3644-3650. PubMed id: 21810173
Date:
13-Jun-11     Release date:   14-Sep-11    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q10714  (ACE_DROME) -  Angiotensin-converting enzyme
Seq:
Struc:
 
Seq:
Struc:
615 a.a.
596 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.4.15.1  - Peptidyl-dipeptidase A.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II.
      Cofactor: Zinc
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   1 term 
  Biological process     proteolysis   1 term 
  Biochemical function     metallopeptidase activity     2 terms  

 

 
FEBS J 278:3644-3650 (2011)
PubMed id: 21810173  
 
 
Structural characterization of angiotensin I-converting enzyme in complex with a selenium analogue of captopril.
M.Akif, G.Masuyer, S.L.Schwager, B.J.Bhuyan, G.Mugesh, R.E.Isaac, E.D.Sturrock, K.R.Acharya.
 
  ABSTRACT  
 
No abstract given.