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PDBsum entry 3wd5

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protein Protein-protein interface(s) links
Immune system PDB id
3wd5
Jmol
Contents
Protein chains
152 a.a.
213 a.a.
214 a.a.
Waters ×34
PDB id:
3wd5
Name: Immune system
Title: Crystal structure of tnfalpha in complex with adalimumab fab
Structure: Tumor necrosis factor. Chain: a. Fragment: tumor necrosis factor, soluble form. Synonym: tnfalpha. Engineered: yes. Adalimumab light chain. Chain: l. Engineered: yes. Adalimumab heavy chain.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnfa. Expressed in: escherichia coli. Expression_system_taxid: 562. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
Resolution:
3.10Å     R-factor:   0.191     R-free:   0.275
Authors: S.Hu,S.Y.Liang,Y.J.Guo,Z.Y.Lou
Key ref: S.Hu et al. Comparison of the inhibition mechanisms of adalimumab infliximab in treating tnfalpha-Associated diseases f molecular view. To be published, .
Date:
06-Jun-13     Release date:   14-Aug-13    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P01375  (TNFA_HUMAN) -  Tumor necrosis factor
Seq:
Struc:
233 a.a.
152 a.a.*
Protein chain
No UniProt id for this chain
Struc: 213 a.a.
Protein chain
No UniProt id for this chain
Struc: 214 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   1 term 
  Biological process     immune response   1 term 
  Biochemical function     tumor necrosis factor receptor binding     1 term