PDBsum entry 3vpm

Oxidoreductase

PDB id: 3vpm

Contents

Protein chains

286 a.a.

Metals

_FE ×2

_MG ×2

Waters ×46

PDB id:

3vpm

Name:

Oxidoreductase

Title:

Crystal structure of human ribonucleotide reductase subunit m2 (hrrm2) mutant

Structure:

Ribonucleoside-diphosphate reductase subunit m2. Chain: a, b. Fragment: unp residues 66-350. Synonym: ribonucleotide reductase small chain, ribonucleotide reductase small subunit. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: rr2, rrm2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.70Å R-factor: 0.209 R-free: 0.249

Authors:

X.Chen,Z.Xu,H.Liu,L.Zhang,B.Chen,L.Zhu,C.Yang,W.Zhu,J.Shao

Key ref:

X.Chen et al. Essential role of e106 in the proton-Coupled electron transfer in human ribonucleotide reductase m2 subunit. To be published, .

Date:

05-Mar-12 Release date: 06-Mar-13

Protein chains

P31350  (RIR2_HUMAN) -  Ribonucleoside-diphosphate reductase subunit M2 from Homo sapiens

Seq: 389 a.a.

Struc: 286 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.1.17.4.1 - ribonucleoside-diphosphate reductase.
• Reaction: a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol
• Cofactor: Fe(3+) or adenosylcob(III)alamin or Mn(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site